Talo Systems is an early-stage therapeutics focused company based in Singapore. Led by a team of experienced drug development and computer scientists, we are a multi-disciplinary team of software developers, artificial intelligence engineers, bioinformaticians, chemists, and more. Together, our team is working to change the way that therapeutics are developed — at all phases of pre-clinical research and development.
A successful candidate will have a good understanding of computational chemistry principles and drug discovery, and possess the necessary problem solving and communication skills to collaborate in a multi-discipline team setting. The position requires an individual with a strong work ethic who is highly motivated and excited to work in a collaborative environment.
Responsibilities:
- Use of in silico method to support design of small molecule drugs targeting disease relevant pathways
- Use of in silico methods to support identification and discovery of disease relevant targets and pathways
- Responsible for route selection, design, and multi-step synthesis
- Keep up to date knowledge of relevant literature and technology methodologies
- Must possess good scientific problem-solving ability
Requirements:
- Degree or Ph.D. in relevant subjects such as Computational Chemistry (preferred) or Organic Chemistry
- Demonstrated record of productivity in Medicinal or synthetic chemistry and Molecular Dynamics Simulation research as evidenced by publications and/or patents
- Medicinal Chemistry knowledge and experience – 3 years minimum
- Knowledge and prior experience in structure-based and ligand-based drug design, HTVS and quantum-mechanical calculations
- Proficient in related softwares such as: Gaussian, AutoDock, Maestro Schrodinger, Assisted Model Building with Energy Refinement, and Visual Molecular Dynamics
- Proficient in programming languages such as: R, Python, Bash and Fortran
- Excellent scientific problem-solving skills with the ability to perform research independently
- Strong interpersonal and communication skills (both written and verbal)
- Ability to work collaboratively in a team